clonazepam tolerance , Provigil may affect the way other medicines work, and other medicines may affect how Provigil works. Ultram And Drug And Information , Patients should be cautioned regarding the potential increased risk of pregnancy when using steroidal contraceptives (including depot or implantable contraceptives) with Provigil and for one month after discontinuation of therapy (See Carcinogenesis, Mutagenesis, Impairment of Fertility and Pregnancy).